Is Femara better than Clomid for PCOS? A randomized controlled trial.
Legro RS, Brzyski RG, Diamond MP, Casson P, Diamond MP for review.
We designed a double-blind, multicenter, randomized trial to test the hypothesis that letrozole would be superior to clomid as an infertility treatment and would have a similar safety profile.
Letrozole was used under an Investigational New Drug application (number 101,671) to the Food and Drug Administration (FDA). The institutional review board at each center approved the protocol, and all participants (women and their male partners) gave written informed consent. Enrollment began in February 2009 and was completed in January 2012. All data entry, data management, and analyses were coordinated or performed at the Collaborative Center for Statistics in Science at Yale University, the data coordinating center for this study. All drafts of the manuscript were written by the first and last authors with input from all the authors. The steering committee of the Reproductive Medicine Network vouches for the accuracy and completeness of the data. All the authors vouch for the fidelity of the study to the protocol.
A total of 750 infertile women 18 to 40 years of age with the polycystic ovary syndrome who had no major medical disorders and who were not taking confounding medications (primarily sex steroids, other infertility drugs, and insulin sensitizers, as described below), their male partners, and their neonates participated in the study.
Is Femara better than Clomid for PCOS? A randomized trial.
Legro RS, Brzyski RG, Diamond MP, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Huang H, Yan Q, Haisenleder DJ, Barnhart KT, Bates GW, Usadi R, Lucidi R, Baker V, Trussell JC, Krawetz SA, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang M, Zhang H, National Institute of Child Health and Human Development Reproductive Medicine Network.
Legro RS, Casson P, Brzyski RG, Diamond MP, Coutifaris C, Casson P, Brzyski RG, Christman GM, Trussell JC, Krawetz SA, Snyder PJ, Ohl D, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Santoro N, Eisenberg E, Zhang M, Zhang M, Guo Q, Liu H, Liu H, National Institute of Child Health and Human Development Reproductive Medicine Network.
Is Femara better than Clomid for PCOS? A randomized controlled trial.
Legro RS, Brzyski RG, Diamond MP, et al; NICHD Reproductive Medicine Network. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(2):119–129.
Meadows GM, Diamond MP, Coutifaris C, Carr BR, Diamond MP for the purposes of this study, and their families.
Letrozole is more effective than clomiphene for the treatment of infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(2):119–129.
In IVF cycles, which medication are chosen? A randomized controlled trial.
Letrozole is more effective than clomiphene for the treatment of infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(2):119–129.
Meadows GM, Brzyski RG, Diamond MP, et al; NICHD Reproductive Medicine Network. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(2):119–129.
Letrozole is more effective than clomiphene for the treatment of infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(2):119–129.
Letrozole is more effective than clomiphene for the treatment of infertility in the polycystic ovary syndrome.
Is Femara better than Clomid for PCOS?
I have been trying for 5 months and have been trying with no avail. I moved to a larger apartment and now have 2 kids. I moved in January and had my period the first month but the second month I miscarried. My doctor is now seeing me for follow up visits in March and June. Are my chances of conceiving better with this drug?
I have been trying for 5 months and have been trying with no avail. I moved to a larger apartment and now have 2 kids. I moved in January and had my period the first month but the second month I miscarried. My doctor is now seeing me for follow up visits in March and June. Are my chances better with this drug?
Your chances of conceiving are better with this drug. I have been trying for 5 months and have been trying with no avail. I moved to a larger apartment and now have 2 kids. I moved in January and had my period the first month but the second month I miscarried. Your chances are better with this drug if you: are a woman of childbearing age (18 years and over)
do not smoke or have a medical condition that makes you more likely to have a problem with conception (premature ovarian rupture, multiple pregnancy, ectopic pregnancies)
are not taking other fertility drugs (clomiphene, letrozole, letrozole acetate, letrozole citrate, letrozole tripeptide) for more than 3 months
Letrozole is currently the first-line treatment at InVia for ovulation induction in patients with unexplained infertility.
